Compound Detail
CHEMBL5435778
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5435778 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LSQRAFQKNVWVCM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
451.6
MW (Da)
4.65
ALogP
5
HBA
0
HBD
45.5
PSA (Ų)
0.41
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Raji CHEMBL614628 | IC50 | 5.07 | 4.98 | 8500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Raji | IC50 | = | 8500.0 | nM | 5.07 | Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cel... | 37465293 |
| Raji | IC50 | = | 13000.0 | nM | 4.89 | Cytotoxicity against PD-1 negative human Raji cells measured after 24 hrs by Cel... | 37465293 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37465293 | 10.1021/acsmedchemlett.3c00063 | Raji | 2 |
Data from ChEMBL 36 via Core Engine