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Assay Detail

CHEMBL5363656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 5 days by EZMTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong <i>In Vivo</i> Anticancer Activity.
Hou W, Chen Z, Pan C, Ni M, Ruan H, Song J, Lu S, Bhasin A, Ruan BH.
ACS Med Chem Lett (2023) 14 : 920 -928
PubMed 37465295 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.90 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3639788 TELAGLENASTAT 2.0 1 7.40
CHEMBL5397149 1 6.40
CHEMBL5395264 1 6.12
CHEMBL5440854 1 5.80
CHEMBL5419380 1 5.77
CHEMBL5416840 1 5.52
CHEMBL5411097 1 5.10
CHEMBL5429363 1 5.05
CHEMBL5426005 1 -
CHEMBL5401983 1 -
CHEMBL5430605 1 -
CHEMBL5427281 1 -
CHEMBL5429695 1 -
CHEMBL5407538 1 -
CHEMBL5406556 1 -
CHEMBL5422979 1 -
CHEMBL5423195 1 -
CHEMBL5418186 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3639788 TELAGLENASTAT IC50 = 40.0 nM 7.40
CHEMBL5397149 IC50 = 400.0 nM 6.40
CHEMBL5395264 IC50 = 750.0 nM 6.12
CHEMBL5440854 IC50 = 1600.0 nM 5.80
CHEMBL5419380 IC50 = 1700.0 nM 5.77
CHEMBL5416840 IC50 = 3000.0 nM 5.52
CHEMBL5411097 IC50 = 8000.0 nM 5.10
CHEMBL5429363 IC50 = 9000.0 nM 5.05
CHEMBL5426005 IC50 > 10000.0 nM -
CHEMBL5401983 IC50 > 10000.0 nM -
CHEMBL5430605 IC50 > 10000.0 nM -
CHEMBL5427281 IC50 > 10000.0 nM -
CHEMBL5429695 IC50 > 10000.0 nM -
CHEMBL5407538 IC50 > 10000.0 nM -
CHEMBL5406556 IC50 > 10000.0 nM -
CHEMBL5422979 IC50 > 10000.0 nM -
CHEMBL5423195 IC50 > 10000.0 nM -
CHEMBL5418186 IC50 > 10000.0 nM -