Compound Detail
CHEMBL5426005
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Basic Information
| ChEMBL ID | CHEMBL5426005 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FIUOKBUDUBAHJU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
368.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| H22 CHEMBL614998 | IC50 | 5.25 | 5.25 | 5600.0 | 1 |
| Thioredoxin reductase CHEMBL3638339 | IC50 | 4.89 | 4.89 | 13000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| H22 | IC50 | = | 5600.0 | nM | 5.25 | Antiproliferative activity against mouse H22 cells assessed as cell growth inhib... | 37465295 |
| Thioredoxin reductase | IC50 | = | 13000.0 | nM | 4.89 | Negative allosteric modulator activity at Escherichia coli TrxR using DTNB as su... | 37465295 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37465295 | 10.1021/acsmedchemlett.2c00470 | Unchecked | 1 |
| 37465295 | 10.1021/acsmedchemlett.2c00470 | Glutaminase kidney isoform, mitochondrial | 1 |
| 37465295 | 10.1021/acsmedchemlett.2c00470 | Thioredoxin reductase | 1 |
| 37465295 | 10.1021/acsmedchemlett.2c00470 | H22 | 1 |
| 37465295 | 10.1021/acsmedchemlett.2c00470 | A549 | 1 |
Data from ChEMBL 36 via Core Engine