Assay Detail
Binding
CHEMBL5364539
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylscopolamine chloride from human muscarinic M3 receptor incubated for 2 hrs by radioligand binding assay
21
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of M<sub>3</sub> Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 9.06 | 10.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426968 | — | — | 1 | 10.20 |
| CHEMBL5395712 | — | — | 2 | 9.80 |
| CHEMBL5408238 | — | — | 2 | 9.70 |
| CHEMBL5402697 | — | — | 1 | 9.60 |
| CHEMBL5409010 | — | — | 1 | 9.60 |
| CHEMBL5399363 | — | — | 2 | 9.60 |
| CHEMBL5410533 | — | — | 2 | 9.50 |
| CHEMBL5397387 | — | — | 1 | 9.20 |
| CHEMBL5417689 | — | — | 1 | 9.20 |
| CHEMBL5433640 | — | — | 1 | 9.00 |
| CHEMBL5439180 | — | — | 1 | 8.60 |
| CHEMBL5430170 | — | — | 2 | 8.50 |
| CHEMBL5419862 | — | — | 1 | 8.50 |
| CHEMBL5420551 | — | — | 1 | 7.60 |
| CHEMBL5404020 | — | — | 2 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426968 | — | Ki | = | 0.0631 | nM | 10.20 |
| CHEMBL5395712 | — | Ki | = | 0.1585 | nM | 9.80 |
| CHEMBL5395712 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL5408238 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL5399363 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL5409010 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL5402697 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL5410533 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL5399363 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL5417689 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL5408238 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL5397387 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL5433640 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5439180 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL5430170 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL5419862 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL5410533 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL5430170 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL5420551 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL5404020 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL5404020 | — | Ki | > | 50.12 | nM | - |