Assay Detail

CHEMBL5364571

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Binding

Inhibition of human recombinant PDE4A4 expressed in baculovirus expression system using cAMP as substrate by radiometric assay

ChEMBL ↗

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Target

3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗

Open DB target context

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3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 3',5'-cyclic-AMP phosphodiesterase 4A

CHEMBL254

Anchored from Assay target.

Protein identity 3',5'-cyclic-AMP phosphodiesterase 4A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Optimization of M<sub>3</sub> Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD.

Rizzi A, Amari G, Pivetti F, Delcanale M, Amadei F, Pappani A, Fornasari L, Villetti G, Marchini G, Pisano AR, Pitozzi V, Pittelli MG, Trevisani M, Salvadori M, Cenacchi V, Fioni A, Puccini P, Civelli M, Patacchini R, Baker-Glenn C, Van de Poël H, Blackaby W, Nash K, Armani E.
J Med Chem (2023) 66 : 11476 -11497
PubMed 37561958 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.50	10.50

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5417689	—	—	1	10.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5417689	—	IC50	=	0.03162	nM	10.50