Assay Detail
Functional
CHEMBL5365328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against ERalpha positive human T47D cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 5.44 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 9.55 |
| CHEMBL5425664 | — | — | 1 | 6.07 |
| CHEMBL5394327 | — | — | 1 | 5.84 |
| CHEMBL5394081 | — | — | 1 | 5.77 |
| CHEMBL5416527 | — | — | 1 | 5.77 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 5.75 |
| CHEMBL5401690 | — | — | 1 | 5.75 |
| CHEMBL5440300 | — | — | 1 | 5.75 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | 5.71 |
| CHEMBL5418805 | — | — | 1 | 5.71 |
| CHEMBL5428365 | — | — | 1 | 5.69 |
| CHEMBL5396545 | — | — | 1 | 5.65 |
| CHEMBL5408790 | — | — | 1 | 5.59 |
| CHEMBL5418245 | — | — | 1 | 5.59 |
| CHEMBL5431311 | — | — | 1 | 5.55 |
| CHEMBL5437045 | — | — | 1 | 5.55 |
| CHEMBL5397595 | — | — | 1 | 5.54 |
| CHEMBL5438291 | — | — | 1 | 5.52 |
| CHEMBL5440184 | — | — | 1 | 5.51 |
| CHEMBL5430579 | — | — | 1 | 5.50 |
| CHEMBL5420136 | — | — | 1 | 5.49 |
| CHEMBL5423157 | — | — | 1 | 5.49 |
| CHEMBL5425101 | — | — | 1 | 5.47 |
| CHEMBL5412552 | — | — | 1 | 5.45 |
| CHEMBL5425938 | — | — | 1 | 5.45 |
| CHEMBL5414441 | — | — | 1 | 5.42 |
| CHEMBL5424737 | — | — | 1 | 5.42 |
| CHEMBL5425620 | — | — | 1 | 5.41 |
| CHEMBL5407548 | — | — | 1 | 5.39 |
| CHEMBL1077183 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5425664 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5394327 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5394081 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5416527 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5401690 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5440300 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5418805 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5428365 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5396545 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5408790 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL5418245 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5437045 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL5431311 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL5397595 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL5438291 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5440184 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL5430579 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5420136 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5423157 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5425101 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL5412552 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5425938 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL5414441 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5424737 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL5425620 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL5407548 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL1077183 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL5416288 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL5394507 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL5404844 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5434346 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL5410726 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL5438152 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL5396802 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL5399502 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL5431315 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL5440727 | — | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL5396353 | — | IC50 | = | 13350.0 | nM | 4.88 |
| CHEMBL5423453 | — | IC50 | = | 13550.0 | nM | 4.87 |
| CHEMBL5428020 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL5397320 | — | IC50 | = | 17960.0 | nM | 4.75 |
| CHEMBL5400134 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL5406235 | — | IC50 | = | 19860.0 | nM | 4.70 |
| CHEMBL5397917 | — | IC50 | = | 20180.0 | nM | 4.70 |
| CHEMBL5408618 | — | IC50 | = | 24570.0 | nM | 4.61 |
| CHEMBL5434697 | — | IC50 | = | 27740.0 | nM | 4.56 |
| CHEMBL5419933 | — | IC50 | > | 31000.0 | nM | - |