Assay Detail
Functional
CHEMBL5365795
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Antiproliferative activity against human A2780 cells assessed as cell growth inhibition
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.79 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394343 | — | — | 1 | 8.62 |
| CHEMBL5404254 | — | — | 1 | 8.52 |
| CHEMBL5398077 | — | — | 1 | 8.23 |
| CHEMBL5432491 | — | — | 1 | 7.51 |
| CHEMBL5408614 | — | — | 1 | 7.47 |
| CHEMBL5428751 | — | — | 1 | 7.42 |
| CHEMBL5401142 | — | — | 1 | 7.39 |
| CHEMBL5408297 | — | — | 1 | 7.16 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | - |
| CHEMBL5434442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394343 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5404254 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5398077 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5432491 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL5408614 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL5428751 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL5401142 | — | IC50 | = | 41.1 | nM | 7.39 |
| CHEMBL5408297 | — | IC50 | = | 69.2 | nM | 7.16 |
| CHEMBL566757 | DAPORINAD | IC50 | < | 3.0 | nM | - |
| CHEMBL5434442 | — | IC50 | < | 4.0 | nM | - |