Assay Detail
Binding
CHEMBL5369550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AKT1 (unknown origin)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 9.46 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407182 | — | — | 1 | 10.70 |
| CHEMBL5406146 | — | — | 1 | 10.64 |
| CHEMBL5414576 | — | — | 1 | 10.46 |
| CHEMBL5398425 | — | — | 1 | 10.44 |
| CHEMBL5437264 | — | — | 1 | 10.28 |
| CHEMBL5428430 | — | — | 1 | 10.27 |
| CHEMBL5400934 | — | — | 1 | 10.08 |
| CHEMBL5408482 | — | — | 1 | 10.04 |
| CHEMBL5438374 | — | — | 1 | 9.92 |
| CHEMBL5399312 | — | — | 1 | 9.85 |
| CHEMBL5411877 | — | — | 1 | 9.66 |
| CHEMBL5405650 | — | — | 1 | 9.52 |
| CHEMBL5422811 | — | — | 1 | 9.40 |
| CHEMBL5430096 | — | — | 1 | 9.38 |
| CHEMBL5405389 | — | — | 1 | 9.35 |
| CHEMBL5404104 | — | — | 1 | 9.21 |
| CHEMBL5425811 | — | — | 1 | 8.96 |
| CHEMBL5440366 | — | — | 1 | 8.72 |
| CHEMBL5409113 | — | — | 1 | 8.55 |
| CHEMBL5407425 | — | — | 1 | 8.49 |
| CHEMBL5395510 | — | — | 1 | 8.20 |
| CHEMBL5399565 | — | — | 1 | 6.04 |
| CHEMBL5400932 | — | — | 1 | - |
| CHEMBL5424777 | — | — | 1 | - |
| CHEMBL5432522 | — | — | 1 | - |
| CHEMBL5404131 | — | — | 1 | - |
| CHEMBL5423093 | — | — | 1 | - |
| CHEMBL5425319 | — | — | 1 | - |
| CHEMBL5400666 | — | — | 1 | - |
| CHEMBL5421280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407182 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5406146 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL5414576 | — | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL5398425 | — | IC50 | = | 0.036 | nM | 10.44 |
| CHEMBL5437264 | — | IC50 | = | 0.053 | nM | 10.28 |
| CHEMBL5428430 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL5400934 | — | IC50 | = | 0.083 | nM | 10.08 |
| CHEMBL5408482 | — | IC50 | = | 0.091 | nM | 10.04 |
| CHEMBL5438374 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL5399312 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5411877 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL5405650 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5422811 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5430096 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5405389 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5404104 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL5425811 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5440366 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5409113 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5407425 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5395510 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5399565 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL5425278 | — | IC50 | - | — | - | |
| CHEMBL5424919 | — | IC50 | - | — | - | |
| CHEMBL5412156 | — | IC50 | - | — | - | |
| CHEMBL5426560 | — | IC50 | < | 0.01 | nM | - |
| CHEMBL5428749 | — | IC50 | - | — | - | |
| CHEMBL5421280 | — | IC50 | < | 0.01 | nM | - |
| CHEMBL5400666 | — | IC50 | - | — | - | |
| CHEMBL5425319 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5423093 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5404131 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5432522 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5424777 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5400932 | — | IC50 | > | 1000.0 | nM | - |