Assay Detail
Functional
CHEMBL5370496
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Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
18
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 9 | - | - |
| IC50 | 9 | 8.69 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428624 | — | — | 2 | 10.40 |
| CHEMBL5397139 | — | — | 2 | 10.10 |
| CHEMBL5436814 | — | — | 2 | 9.15 |
| CHEMBL5430183 | — | — | 1 | 8.96 |
| CHEMBL4210516 | — | — | 2 | 8.70 |
| CHEMBL5438210 | — | — | 2 | 7.89 |
| CHEMBL5422307 | — | — | 2 | 7.75 |
| CHEMBL5087988 | — | — | 2 | 7.72 |
| CHEMBL5422756 | — | — | 2 | 7.52 |
| CHEMBL5438112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428624 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5397139 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5436814 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL5430183 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4210516 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5438210 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5422307 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5087988 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5422756 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5422756 | — | Inhibition | - | % | - | |
| CHEMBL5397139 | — | Inhibition | - | % | - | |
| CHEMBL5428624 | — | Inhibition | - | % | - | |
| CHEMBL5436814 | — | Inhibition | - | % | - | |
| CHEMBL5438112 | — | Inhibition | - | % | - | |
| CHEMBL4210516 | — | Inhibition | - | % | - | |
| CHEMBL5087988 | — | Inhibition | - | % | - | |
| CHEMBL5422307 | — | Inhibition | - | % | - | |
| CHEMBL5438210 | — | Inhibition | - | % | - |