Assay Detail
Binding
CHEMBL5370973
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Inhibition of DENV/NS5 RNA-dependent RNA polymerase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Perspectives on the current antiviral developments towards RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) domains of dengue virus non-structural protein 5 (DENV-NS5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.72 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471282 | AVICULARIN | — | 1 | 5.77 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.77 |
| CHEMBL402947 | SPIRAEOSIDE | — | 1 | 5.72 |
| CHEMBL82242 | QUERCITRIN | — | 1 | 5.68 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471282 | AVICULARIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL402947 | SPIRAEOSIDE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL82242 | QUERCITRIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL226335 | RUTIN | IC50 | = | 2100.0 | nM | 5.68 |