Assay Detail
Binding
CHEMBL5371022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IRAK4 (unknown origin) by Z-LYTE enzymatic kinase assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzofuran IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.77 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394332 | — | — | 1 | 8.68 |
| CHEMBL5425478 | — | — | 1 | 8.59 |
| CHEMBL4467170 | — | — | 1 | 8.54 |
| CHEMBL4473269 | — | — | 1 | 8.21 |
| CHEMBL5430303 | — | — | 1 | 8.13 |
| CHEMBL5405160 | — | — | 1 | 8.06 |
| CHEMBL5434407 | — | — | 1 | 7.99 |
| CHEMBL5416082 | — | — | 1 | 7.94 |
| CHEMBL5422634 | — | — | 1 | 7.90 |
| CHEMBL5398628 | — | — | 1 | 7.89 |
| CHEMBL5397218 | — | — | 1 | 7.85 |
| CHEMBL5423322 | — | — | 1 | 7.85 |
| CHEMBL5406638 | — | — | 1 | 7.73 |
| CHEMBL5419418 | — | — | 1 | 7.66 |
| CHEMBL5408706 | — | — | 1 | 7.64 |
| CHEMBL5438469 | — | — | 1 | 7.61 |
| CHEMBL5422223 | — | — | 1 | 7.60 |
| CHEMBL5438284 | — | — | 1 | 7.57 |
| CHEMBL5405534 | — | — | 1 | 7.54 |
| CHEMBL5400205 | — | — | 1 | 7.52 |
| CHEMBL5428262 | — | — | 1 | 7.49 |
| CHEMBL5402826 | — | — | 1 | 7.38 |
| CHEMBL5407111 | — | — | 1 | 7.21 |
| CHEMBL5437103 | — | — | 1 | 7.20 |
| CHEMBL5430898 | — | — | 1 | 7.18 |
| CHEMBL5402181 | — | — | 1 | 7.13 |
| CHEMBL5413969 | — | — | 1 | - |
| CHEMBL5400112 | — | — | 1 | - |
| CHEMBL5437617 | — | — | 1 | - |
| CHEMBL5400523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394332 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5425478 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4467170 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4473269 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5430303 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5405160 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5434407 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5416082 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5422634 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL5398628 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL5397218 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5423322 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5406638 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL5419418 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL5408706 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL5438469 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL5422223 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL5438284 | — | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL5405534 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL5400205 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL5428262 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL5402826 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL5407111 | — | IC50 | = | 60.9 | nM | 7.21 |
| CHEMBL5437103 | — | IC50 | = | 62.7 | nM | 7.20 |
| CHEMBL5430898 | — | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL5402181 | — | IC50 | = | 73.8 | nM | 7.13 |
| CHEMBL5418827 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5402129 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5407495 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5405946 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5404422 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5418292 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5400523 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5437617 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5400112 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5413969 | — | IC50 | > | 100.0 | nM | - |