Compound Detail
CHEMBL5419418
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Basic Information
| ChEMBL ID | CHEMBL5419418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IKCVUEWREOHQQP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
448.5
MW (Da)
3.91
ALogP
7
HBA
2
HBD
100.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 CHEMBL3778 | IC50 | 7.66 | 7.66 | 22.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-1 receptor-associated kinase 4 | IC50 | = | 22.1 | nM | 7.66 | Inhibition of IRAK4 (unknown origin) by Z-LYTE enzymatic kinase assay | 37163947 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37163947 | 10.1016/j.ejmech.2023.115453 | Interleukin-1 receptor-associated kinase 4 | 1 |
Data from ChEMBL 36 via Core Engine