Assay Detail
Functional
CHEMBL5373318
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability by alamar blue staining based assay
22
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.11 | 4.22 |
| pIC50 | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440341 | — | — | 2 | 4.22 |
| CHEMBL3935992 | — | — | 2 | 4.03 |
| CHEMBL5425437 | — | — | 1 | - |
| CHEMBL5411782 | — | — | 1 | - |
| CHEMBL5403435 | — | — | 1 | - |
| CHEMBL5429808 | — | — | 1 | - |
| CHEMBL5429543 | — | — | 1 | - |
| CHEMBL5434758 | — | — | 1 | - |
| CHEMBL5417383 | — | — | 1 | - |
| CHEMBL5429654 | — | — | 1 | - |
| CHEMBL5440081 | — | — | 1 | - |
| CHEMBL5421243 | — | — | 1 | - |
| CHEMBL5403250 | — | — | 1 | - |
| CHEMBL5425061 | — | — | 1 | - |
| CHEMBL5408305 | — | — | 1 | - |
| CHEMBL5410192 | — | — | 2 | - |
| CHEMBL5440297 | — | — | 2 | - |
| CHEMBL5408594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440341 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4440341 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3935992 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL3935992 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5425437 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5411782 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5403435 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5429808 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5429543 | — | pIC50 | - | — | - | |
| CHEMBL5434758 | — | pIC50 | - | — | - | |
| CHEMBL5417383 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5429654 | — | pIC50 | - | — | - | |
| CHEMBL5408594 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5440081 | — | IC50 | > | 251188.64 | nM | - |
| CHEMBL5403250 | — | pIC50 | - | — | - | |
| CHEMBL5425061 | — | pIC50 | - | — | - | |
| CHEMBL5408305 | — | pIC50 | - | — | - | |
| CHEMBL5410192 | — | IC50 | = | 125892.54 | nM | - |
| CHEMBL5440297 | — | IC50 | = | 158489.32 | nM | - |
| CHEMBL5410192 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL5440297 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL5421243 | — | pIC50 | - | — | - |