Assay Detail
Binding
CHEMBL5373404
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Agonist activity at RLucII/GFP10-tagged beta-arrestin-1 (unknown origin) recruitment expressed in HEK293 cells co-expressing human UT assessed as beta-arrestin recruitment by BRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.86 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417669 | — | — | 1 | 9.31 |
| CHEMBL5414487 | — | — | 1 | 8.03 |
| CHEMBL593662 | UROTENSIN-II | — | 1 | 7.69 |
| CHEMBL5421473 | — | — | 1 | 7.02 |
| CHEMBL5401911 | — | — | 1 | 6.93 |
| CHEMBL5421352 | — | — | 1 | 6.76 |
| CHEMBL5422077 | — | — | 1 | 6.07 |
| CHEMBL5416714 | — | — | 1 | 6.03 |
| CHEMBL5396036 | — | — | 1 | 5.92 |
| CHEMBL5423896 | — | — | 1 | 5.91 |
| CHEMBL5406651 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417669 | — | EC50 | = | 0.4898 | nM | 9.31 |
| CHEMBL5414487 | — | EC50 | = | 9.333 | nM | 8.03 |
| CHEMBL593662 | UROTENSIN-II | EC50 | = | 20.42 | nM | 7.69 |
| CHEMBL5421473 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL5401911 | — | EC50 | = | 117.49 | nM | 6.93 |
| CHEMBL5421352 | — | EC50 | = | 173.78 | nM | 6.76 |
| CHEMBL5422077 | — | EC50 | = | 851.14 | nM | 6.07 |
| CHEMBL5416714 | — | EC50 | = | 933.25 | nM | 6.03 |
| CHEMBL5396036 | — | EC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL5423896 | — | EC50 | = | 1230.27 | nM | 5.91 |
| CHEMBL5406651 | — | EC50 | = | 1778.28 | nM | 5.75 |