Assay Detail
Functional
CHEMBL5373422
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Ex vivo modulatory effect on URP-induced contractile activity in Sprague-Dawley rat aortic ring (Rvb = 8.06 +/- 0.27 No_unit)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.06 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422077 | — | — | 1 | 8.81 |
| CHEMBL5401911 | — | — | 1 | 8.48 |
| CHEMBL5396036 | — | — | 1 | 8.43 |
| CHEMBL5421352 | — | — | 1 | 8.39 |
| CHEMBL5414487 | — | — | 1 | 8.09 |
| CHEMBL5423896 | — | — | 1 | 7.87 |
| CHEMBL5406651 | — | — | 1 | 7.79 |
| CHEMBL5416714 | — | — | 1 | 7.36 |
| CHEMBL5421473 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422077 | — | EC50 | = | 1.549 | nM | 8.81 |
| CHEMBL5401911 | — | EC50 | = | 3.311 | nM | 8.48 |
| CHEMBL5396036 | — | EC50 | = | 3.715 | nM | 8.43 |
| CHEMBL5421352 | — | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL5414487 | — | EC50 | = | 8.128 | nM | 8.09 |
| CHEMBL5423896 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL5406651 | — | EC50 | = | 16.22 | nM | 7.79 |
| CHEMBL5416714 | — | EC50 | = | 43.65 | nM | 7.36 |
| CHEMBL5421473 | — | EC50 | = | 44.67 | nM | 7.35 |