Assay Detail
Functional
CHEMBL5374305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-proliferative activity against human U-87 MG cells assessed as cell viability incubated for 2 hrs by CCK8 assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Bioevaluation of 3-(Arylmethylene)indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.63 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397688 | — | — | 1 | 5.45 |
| CHEMBL5409597 | — | — | 1 | 5.25 |
| CHEMBL5399967 | — | — | 1 | 5.14 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.14 |
| CHEMBL5437494 | — | — | 1 | 5.10 |
| CHEMBL5420275 | — | — | 1 | 4.98 |
| CHEMBL5396541 | — | — | 1 | 4.90 |
| CHEMBL5413968 | — | — | 1 | 4.68 |
| CHEMBL5422449 | — | — | 1 | 4.63 |
| CHEMBL5418850 | — | — | 1 | 4.55 |
| CHEMBL5414661 | — | — | 1 | 4.52 |
| CHEMBL5417863 | — | — | 1 | 4.38 |
| CHEMBL5433226 | — | — | 1 | 4.37 |
| CHEMBL5431878 | — | — | 1 | 4.26 |
| CHEMBL5396858 | — | — | 1 | 4.23 |
| CHEMBL5417824 | — | — | 1 | 4.13 |
| CHEMBL5428709 | — | — | 1 | 4.12 |
| CHEMBL5413828 | — | — | 1 | 4.06 |
| CHEMBL5419481 | — | — | 1 | 4.00 |
| CHEMBL5416862 | — | — | 1 | - |
| CHEMBL5401239 | — | — | 1 | - |
| CHEMBL5401057 | — | — | 1 | - |
| CHEMBL5401841 | — | — | 1 | - |
| CHEMBL5428356 | — | — | 1 | - |
| CHEMBL5435696 | — | — | 1 | - |
| CHEMBL5406905 | — | — | 1 | - |
| CHEMBL5399665 | — | — | 1 | - |
| CHEMBL5408112 | — | — | 1 | - |
| CHEMBL155625 | INDOLE-3-CARBINOL | 2.0 | 1 | - |
| CHEMBL526 | PROPOFOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397688 | — | IC50 | = | 3524.0 | nM | 5.45 |
| CHEMBL5409597 | — | IC50 | = | 5589.0 | nM | 5.25 |
| CHEMBL5399967 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL5437494 | — | IC50 | = | 7963.0 | nM | 5.10 |
| CHEMBL5420275 | — | IC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL5396541 | — | IC50 | = | 12620.0 | nM | 4.90 |
| CHEMBL5413968 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL5422449 | — | IC50 | = | 23170.0 | nM | 4.63 |
| CHEMBL5418850 | — | IC50 | = | 28060.0 | nM | 4.55 |
| CHEMBL5414661 | — | IC50 | = | 30230.0 | nM | 4.52 |
| CHEMBL5417863 | — | IC50 | = | 41280.0 | nM | 4.38 |
| CHEMBL5433226 | — | IC50 | = | 42650.0 | nM | 4.37 |
| CHEMBL5431878 | — | IC50 | = | 55100.0 | nM | 4.26 |
| CHEMBL5396858 | — | IC50 | = | 58300.0 | nM | 4.23 |
| CHEMBL5417824 | — | IC50 | = | 74590.0 | nM | 4.13 |
| CHEMBL5428709 | — | IC50 | = | 75370.0 | nM | 4.12 |
| CHEMBL5413828 | — | IC50 | = | 87790.0 | nM | 4.06 |
| CHEMBL5419481 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5416862 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5401239 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5401057 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5401841 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5428356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5435696 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5406905 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5399665 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5408112 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL155625 | INDOLE-3-CARBINOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL526 | PROPOFOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL5423710 | — | IC50 | > | 100000.0 | nM | - |