Assay Detail
ADMET
CHEMBL5375743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 mins in presence of NADPH by UPLC-MS/MS analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Atypical <i>N</i>-Alkyl to <i>N</i>-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.12 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435819 | — | — | 1 | 5.12 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435819 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL288441 | BOSUTINIB | IC50 | - | — | - |