Assay Detail
Functional
CHEMBL5378952
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Antiproliferative activity against human NB4 cells expressing PML/RARalpha assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
AcGlcAs: A Novel P53-Targeting Arsenical with Potent Cellular Uptake and Cancer Cell Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.24 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | — | 1 | 7.52 |
| CHEMBL1909078 | SODIUM ARSENITE | — | 1 | 6.96 |
| CHEMBL5437355 | — | — | 1 | 6.80 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | 4.0 | 1 | 6.03 |
| CHEMBL5395845 | — | — | 1 | 5.92 |
| CHEMBL5413763 | — | — | 1 | 5.76 |
| CHEMBL5435758 | — | — | 1 | 5.70 |
| CHEMBL5434723 | — | — | 1 | 5.25 |
| CHEMBL5412544 | — | — | 1 | - |
| CHEMBL351769 | ARSANILIC ACID | — | 1 | - |
| CHEMBL5404084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1909078 | SODIUM ARSENITE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5437355 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5483015 | ARSENIC TRIOXIDE | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5395845 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5413763 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5435758 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5434723 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL5412544 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL351769 | ARSANILIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL5404084 | — | IC50 | > | 50000.0 | nM | - |