Assay Detail
Functional
CHEMBL5379464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU-145 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.08 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634108 | — | — | 1 | 5.58 |
| CHEMBL4633379 | — | — | 1 | 5.48 |
| CHEMBL4633484 | — | — | 1 | 5.46 |
| CHEMBL4640789 | — | — | 1 | 5.14 |
| CHEMBL4637348 | — | — | 1 | 4.60 |
| CHEMBL4645485 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634108 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4633379 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4633484 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4640789 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4637348 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4645485 | — | IC50 | = | 60300.0 | nM | 4.22 |