Assay Detail
Binding
CHEMBL5386424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mps1 (unknown origin) incubated for 120 mins in presence of substrate/ATP by ADP-Glo assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.14 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423969 | — | — | 1 | 7.54 |
| CHEMBL5438644 | — | — | 1 | 7.50 |
| CHEMBL5432497 | — | — | 1 | 7.48 |
| CHEMBL5436903 | — | — | 1 | 7.47 |
| CHEMBL5419486 | — | — | 1 | 7.46 |
| CHEMBL2047943 | — | — | 1 | 7.44 |
| CHEMBL5412569 | — | — | 1 | 7.40 |
| CHEMBL5405238 | — | — | 1 | 7.39 |
| CHEMBL5404777 | — | — | 1 | 7.33 |
| CHEMBL5433818 | — | — | 1 | 7.31 |
| CHEMBL5415111 | — | — | 1 | 7.31 |
| CHEMBL5406160 | — | — | 1 | 7.30 |
| CHEMBL5406816 | — | — | 1 | 7.29 |
| CHEMBL5428607 | — | — | 1 | 7.27 |
| CHEMBL5440033 | — | — | 1 | 7.17 |
| CHEMBL5416115 | — | — | 1 | 7.17 |
| CHEMBL5410795 | — | — | 1 | 7.08 |
| CHEMBL5405237 | — | — | 1 | 6.97 |
| CHEMBL5432900 | — | — | 1 | 6.88 |
| CHEMBL5421792 | — | — | 1 | 6.86 |
| CHEMBL5428995 | — | — | 1 | 6.84 |
| CHEMBL5440244 | — | — | 1 | 6.83 |
| CHEMBL5432239 | — | — | 1 | 6.81 |
| CHEMBL5403223 | — | — | 1 | 6.81 |
| CHEMBL5414691 | — | — | 1 | 6.47 |
| CHEMBL5422356 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423969 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5438644 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5432497 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5436903 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5419486 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2047943 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5412569 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5405238 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5404777 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5433818 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5415111 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5406160 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5406816 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5428607 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5440033 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5416115 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5410795 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5405237 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL5432900 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5421792 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5428995 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5440244 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5432239 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5403223 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5414691 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL5422356 | — | IC50 | = | 464.0 | nM | 6.33 |