Assay Detail
Binding
CHEMBL5386735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.86 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248392 | — | — | 1 | 8.30 |
| CHEMBL111038 | — | — | 1 | 8.12 |
| CHEMBL5416668 | — | — | 1 | 6.31 |
| CHEMBL4447196 | — | — | 1 | 6.30 |
| CHEMBL3613691 | — | — | 1 | 5.28 |
| CHEMBL5206476 | — | — | 1 | - |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248392 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL111038 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5416668 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4447196 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3613691 | — | IC50 | = | 5283.0 | nM | 5.28 |
| CHEMBL5206476 | — | IC50 | = | 5300000.0 | nM | - |
| CHEMBL607707 | PELITINIB | IC50 | = | 83000000.0 | nM | - |