Assay Detail
Functional
CHEMBL5388059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against wild type Trypanosoma brucei M1.2 Lister 427 trypomastigotes form assessed as parasite growth inhibition incubated for 48 hrs
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluations of quinolone amides against African trypanosomiasis with improved solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.24 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406814 | — | — | 1 | 7.66 |
| CHEMBL2031131 | — | — | 1 | 7.33 |
| CHEMBL4171343 | — | — | 1 | 7.30 |
| CHEMBL5400512 | — | — | 1 | 7.22 |
| CHEMBL5413915 | — | — | 1 | 7.00 |
| CHEMBL5434449 | — | — | 1 | 6.89 |
| CHEMBL5433907 | — | — | 1 | 6.82 |
| CHEMBL5426284 | — | — | 1 | 6.75 |
| CHEMBL5397254 | — | — | 1 | 6.75 |
| CHEMBL4161155 | — | — | 1 | 6.64 |
| CHEMBL5408292 | — | — | 1 | 6.60 |
| CHEMBL5393768 | — | — | 1 | 6.52 |
| CHEMBL5414568 | — | — | 1 | 6.33 |
| CHEMBL5439162 | — | — | 1 | 6.28 |
| CHEMBL5431717 | — | — | 1 | 6.26 |
| CHEMBL5413859 | — | — | 1 | 6.14 |
| CHEMBL5412681 | — | — | 1 | 6.10 |
| CHEMBL5435312 | — | — | 1 | 6.07 |
| CHEMBL5412118 | — | — | 1 | 6.00 |
| CHEMBL5431656 | — | — | 1 | 5.97 |
| CHEMBL5435951 | — | — | 1 | 5.95 |
| CHEMBL5394145 | — | — | 1 | 5.94 |
| CHEMBL5412052 | — | — | 1 | 5.81 |
| CHEMBL5412770 | — | — | 1 | 5.74 |
| CHEMBL5406369 | — | — | 1 | 5.71 |
| CHEMBL5436970 | — | — | 1 | 5.53 |
| CHEMBL5424089 | — | — | 1 | 5.43 |
| CHEMBL5439977 | — | — | 1 | 5.43 |
| CHEMBL5408711 | — | — | 1 | 5.38 |
| CHEMBL5401587 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406814 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2031131 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4171343 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5400512 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5413915 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5434449 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5433907 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5426284 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5397254 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4161155 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5408292 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5393768 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5414568 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5439162 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5431717 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5413859 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5412681 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5435312 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5412118 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5431656 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5435951 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5394145 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5412052 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5412770 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5406369 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL5436970 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5424089 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5439977 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL5408711 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL5401587 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL5440063 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5398475 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL5401927 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5393944 | — | IC50 | > | 20000.0 | nM | - |