Assay Detail
Functional
CHEMBL5393049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced IL-23 production in IFN-gamma primed human THP-1 cells preincubated for 1 hr followed by LPS stimulation for 18 hrs by sandwich ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal <i>in Vivo</i> Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.61 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437928 | — | — | 1 | 7.70 |
| CHEMBL5408914 | — | — | 1 | 6.72 |
| CHEMBL5440555 | — | — | 1 | 6.52 |
| CHEMBL5433953 | — | — | 1 | 5.82 |
| CHEMBL5413156 | — | — | 1 | 5.68 |
| CHEMBL5425309 | — | — | 1 | 5.67 |
| CHEMBL5430762 | — | — | 1 | 5.46 |
| CHEMBL5393772 | — | — | 1 | 5.19 |
| CHEMBL5422691 | — | — | 1 | 5.16 |
| CHEMBL2107333 | DIMETHYL FUMARATE | 4.0 | 1 | 4.97 |
| CHEMBL5415198 | — | — | 1 | 4.75 |
| CHEMBL589586 | MONOMETHYL FUMARATE | 4.0 | 1 | 4.72 |
| CHEMBL5393827 | — | — | 1 | 4.53 |
| CHEMBL5404675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437928 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5408914 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5440555 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5433953 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5413156 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL5425309 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5430762 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL5393772 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5422691 | — | IC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL2107333 | DIMETHYL FUMARATE | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL5415198 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL589586 | MONOMETHYL FUMARATE | IC50 | = | 18890.0 | nM | 4.72 |
| CHEMBL5393827 | — | IC50 | = | 29470.0 | nM | 4.53 |
| CHEMBL5404675 | — | IC50 | = | 135700.0 | nM | - |