Assay Detail
Functional
CHEMBL5442696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in antagonist mode with target: GPR35
39
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.51 | 6.68 |
| EC50 | 1 | 6.35 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | — | 1 | 6.68 |
| CHEMBL1384502 | — | — | 2 | 6.49 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | 6.45 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 6.35 |
| CHEMBL256470 | — | — | 1 | 6.22 |
| CHEMBL232656 | BX 471 FREE BASE | 2.0 | 1 | 5.97 |
| CHEMBL1256876 | — | — | 1 | 5.50 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | 4.0 | 1 | 5.47 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 5.46 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | 4.0 | 1 | 5.46 |
| CHEMBL4743495 | — | — | 1 | 5.44 |
| CHEMBL487553 | — | — | 1 | 5.44 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 5.43 |
| CHEMBL1766103 | — | — | 1 | 5.41 |
| CHEMBL59898 | — | — | 1 | 5.39 |
| CHEMBL5089005 | — | — | 1 | 5.39 |
| CHEMBL1474387 | — | — | 1 | 5.38 |
| CHEMBL254760 | — | — | 1 | 5.37 |
| CHEMBL4743049 | — | — | 1 | 5.36 |
| CHEMBL531742 | — | — | 1 | 5.35 |
| CHEMBL281350 | SB-224289 | — | 1 | 5.34 |
| CHEMBL2018875 | — | — | 1 | 5.33 |
| CHEMBL5075931 | — | — | 1 | 5.28 |
| CHEMBL259656 | — | — | 1 | 5.27 |
| CHEMBL2111101 | PIMAVANSERIN | 4.0 | 1 | 5.25 |
| CHEMBL567 | PERPHENAZINE | 4.0 | 1 | 5.22 |
| CHEMBL103769 | — | — | 1 | 5.22 |
| CHEMBL2181247 | — | — | 1 | 5.22 |
| CHEMBL1471 | APREPITANT | 4.0 | 1 | 5.21 |
| CHEMBL493982 | VORAPAXAR | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225963 | PYRIDABEN | IC50 | = | 209.52 | nM | 6.68 |
| CHEMBL1384502 | — | IC50 | = | 323.69 | nM | 6.49 |
| CHEMBL1384502 | — | IC50 | = | 345.81 | nM | 6.46 |
| CHEMBL50588 | EMETINE | IC50 | = | 352.52 | nM | 6.45 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | EC50 | = | 444.0 | nM | 6.35 |
| CHEMBL256470 | — | IC50 | = | 608.24 | nM | 6.22 |
| CHEMBL232656 | BX 471 FREE BASE | IC50 | = | 1069.98 | nM | 5.97 |
| CHEMBL1256876 | — | IC50 | = | 3155.17 | nM | 5.50 |
| CHEMBL1200776 | CINACALCET HYDROCHLORIDE | IC50 | = | 3401.33 | nM | 5.47 |
| CHEMBL1230609 | FORETINIB | IC50 | = | 3485.09 | nM | 5.46 |
| CHEMBL1200492 | NEFAZODONE HYDROCHLORIDE | IC50 | = | 3479.24 | nM | 5.46 |
| CHEMBL4743495 | — | IC50 | = | 3601.02 | nM | 5.44 |
| CHEMBL487553 | — | IC50 | = | 3633.11 | nM | 5.44 |
| CHEMBL405355 | NIGULDIPINE | IC50 | = | 3743.05 | nM | 5.43 |
| CHEMBL1766103 | — | IC50 | = | 3929.62 | nM | 5.41 |
| CHEMBL5089005 | — | IC50 | = | 4056.81 | nM | 5.39 |
| CHEMBL59898 | — | IC50 | = | 4111.59 | nM | 5.39 |
| CHEMBL1474387 | — | IC50 | = | 4148.7 | nM | 5.38 |
| CHEMBL254760 | — | IC50 | = | 4246.68 | nM | 5.37 |
| CHEMBL4743049 | — | IC50 | = | 4418.81 | nM | 5.36 |
| CHEMBL531742 | — | IC50 | = | 4438.57 | nM | 5.35 |
| CHEMBL281350 | SB-224289 | IC50 | = | 4581.88 | nM | 5.34 |
| CHEMBL2018875 | — | IC50 | = | 4655.95 | nM | 5.33 |
| CHEMBL5075931 | — | IC50 | = | 5214.15 | nM | 5.28 |
| CHEMBL259656 | — | IC50 | = | 5353.35 | nM | 5.27 |
| CHEMBL2111101 | PIMAVANSERIN | IC50 | = | 5642.31 | nM | 5.25 |
| CHEMBL567 | PERPHENAZINE | IC50 | = | 5966.8 | nM | 5.22 |
| CHEMBL2181247 | — | IC50 | = | 6014.75 | nM | 5.22 |
| CHEMBL103769 | — | IC50 | = | 6025.61 | nM | 5.22 |
| CHEMBL1471 | APREPITANT | IC50 | = | 6238.53 | nM | 5.21 |
| CHEMBL493982 | VORAPAXAR | IC50 | = | 7574.0 | nM | 5.12 |
| CHEMBL3410223 | — | IC50 | = | 7972.4 | nM | 5.10 |
| CHEMBL1201082 | FLUOXETINE HYDROCHLORIDE | IC50 | = | 8296.78 | nM | 5.08 |
| CHEMBL23327 | PURVALANOLA | IC50 | = | 9784.77 | nM | 5.01 |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | IC50 | > | 10000.0 | nM | - |
| CHEMBL535832 | SEROTONIN HYDROCHLORIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL45 | MELATONIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL3215877 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL9506 | DEVAZEPIDE | IC50 | > | 10000.0 | nM | - |