Assay Detail
Functional
CHEMBL5442709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GPCR PRESTO-Tango dose-response in agonist mode with target: ADGRF1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HTLA |
| Category | GPCR beta-arrestin recruitment assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Adhesion G-protein coupled receptor F1 (CHEMBL4523872) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
EUbOPEN Chemogenomics Library - GPCR Dose-Respose
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.69 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 5.69 |
| CHEMBL484929 | — | — | 1 | 5.69 |
| CHEMBL174588 | — | — | 1 | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | 4.0 | 1 | - |
| CHEMBL3989562 | TERAZOSIN HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL1970071 | — | — | 1 | - |
| CHEMBL432038 | — | — | 1 | - |
| CHEMBL2018969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | EC50 | = | 2040.77 | nM | 5.69 |
| CHEMBL484929 | — | EC50 | = | 2041.85 | nM | 5.69 |
| CHEMBL174588 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1200517 | DIHYDROERGOTAMINE MESYLATE | EC50 | > | 10000.0 | nM | - |
| CHEMBL3989562 | TERAZOSIN HYDROCHLORIDE | EC50 | > | 10000.0 | nM | - |
| CHEMBL1970071 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL432038 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2018969 | — | EC50 | > | 10000.0 | nM | - |