Assay Detail
Functional
CHEMBL5500487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.27 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554604 | JORUNNAMYCIN C | — | 1 | 9.49 |
| CHEMBL5557094 | — | — | 1 | 9.31 |
| CHEMBL5542380 | — | — | 1 | 9.18 |
| CHEMBL451147 | RENIERAMYCIN M | — | 1 | 7.72 |
| CHEMBL549905 | JOURNNAMYCIN A | — | 1 | 7.54 |
| CHEMBL5558598 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554604 | JORUNNAMYCIN C | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5557094 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL5542380 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL451147 | RENIERAMYCIN M | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL549905 | JOURNNAMYCIN A | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5558598 | — | IC50 | = | 448.0 | nM | 6.35 |