Assay Detail
Binding
CHEMBL5502133
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Binding affinity to SOST loop2 (unknown origin) by SPR analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.07 | 6.64 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 6.64 |
| CHEMBL5531959 | — | — | 1 | 6.34 |
| CHEMBL455364 | — | — | 1 | 6.27 |
| CHEMBL5531992 | — | — | 1 | 6.02 |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | 5.73 |
| CHEMBL5559172 | — | — | 1 | 5.41 |
| CHEMBL2021342 | — | — | 1 | - |
| CHEMBL9249 | (+)-EPITAXIFOLIN | — | 1 | - |
| CHEMBL5558704 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6466 | COUMARIN | Kd | = | 230.8 | nM | 6.64 |
| CHEMBL5531959 | — | Kd | = | 453.6 | nM | 6.34 |
| CHEMBL455364 | — | Kd | = | 531.9 | nM | 6.27 |
| CHEMBL5531992 | — | Kd | = | 960.0 | nM | 6.02 |
| CHEMBL311498 | CIANIDANOL | Kd | = | 1845.0 | nM | 5.73 |
| CHEMBL5559172 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL2021342 | — | Activity | - | — | - | |
| CHEMBL9249 | (+)-EPITAXIFOLIN | Activity | - | — | - | |
| CHEMBL5558704 | — | Activity | - | — | - |