Assay Detail
Binding
CHEMBL5502134
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Binding affinity to SOST loop3 (unknown origin) by SPR analysis
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the small molecular inhibitors against sclerostin loop3 as potential anti-osteoporosis agents by structural based virtual screening and molecular design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 6 | - | - |
| Kd | 3 | 7.04 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558704 | — | — | 1 | 7.81 |
| CHEMBL2021342 | — | — | 1 | 7.37 |
| CHEMBL5531992 | — | — | 1 | 5.93 |
| CHEMBL9249 | (+)-EPITAXIFOLIN | — | 1 | - |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL5531959 | — | — | 1 | - |
| CHEMBL5559172 | — | — | 1 | - |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | - |
| CHEMBL455364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558704 | — | Kd | = | 15.4 | nM | 7.81 |
| CHEMBL2021342 | — | Kd | = | 42.43 | nM | 7.37 |
| CHEMBL5531992 | — | Kd | = | 1180.0 | nM | 5.93 |
| CHEMBL9249 | (+)-EPITAXIFOLIN | Activity | - | — | - | |
| CHEMBL6466 | COUMARIN | Activity | - | — | - | |
| CHEMBL5531959 | — | Activity | - | — | - | |
| CHEMBL5559172 | — | Activity | - | — | - | |
| CHEMBL311498 | CIANIDANOL | Activity | - | — | - | |
| CHEMBL455364 | — | Activity | - | — | - |