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Assay Detail

CHEMBL5502894

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Binding
Inhibition of equine serum BChE using BTC as substrate incubated for 2 mins by Ellman's method
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Tissue Serum
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL5763) ↗
Type SINGLE PROTEIN
Organism Equus caballus

Publication

Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease.
Chen Y, Zhang W, Li Q, Xie H, Xing S, Lu X, Lyu W, Xiong B, Wang Y, Qu W, Liu W, Chi H, Zhang X, Feng F, Sun H.
Eur J Med Chem (2024) 272 : 116463 -116463
PubMed 38704944 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 6.15 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL95 TACRINE 4.0 1 7.70
CHEMBL5542274 — — 1 7.22
CHEMBL5558992 — — 1 6.89
CHEMBL5556813 — — 1 6.85
CHEMBL5556106 — — 1 6.80
CHEMBL5505765 — — 1 6.77
CHEMBL5556450 — — 1 6.75
CHEMBL5555772 — — 1 6.75
CHEMBL5558573 — — 1 6.75
CHEMBL5557904 — — 1 6.68
CHEMBL5505876 — — 1 6.64
CHEMBL5559511 — — 1 6.55
CHEMBL5512507 — — 1 6.52
CHEMBL5557117 — — 1 6.44
CHEMBL5532571 — — 1 6.40
CHEMBL5523413 — — 1 6.40
CHEMBL5517898 — — 1 6.38
CHEMBL5556895 — — 1 6.37
CHEMBL5532024 — — 1 6.36
CHEMBL5542322 — — 1 6.34
CHEMBL5556256 — — 1 6.23
CHEMBL5505759 — — 1 6.22
CHEMBL5517904 — — 1 6.16
CHEMBL5555797 — — 1 6.11
CHEMBL5523576 — — 1 6.02
CHEMBL5559193 — — 1 5.93
CHEMBL5556197 — — 1 5.90
CHEMBL5558959 — — 1 5.89
CHEMBL5531976 — — 1 5.80
CHEMBL5532209 — — 1 5.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL95 TACRINE IC50 = 20.0 nM 7.70
CHEMBL5542274 — IC50 = 60.0 nM 7.22
CHEMBL5558992 — IC50 = 130.0 nM 6.89
CHEMBL5556813 — IC50 = 140.0 nM 6.85
CHEMBL5556106 — IC50 = 160.0 nM 6.80
CHEMBL5505765 — IC50 = 170.0 nM 6.77
CHEMBL5556450 — IC50 = 180.0 nM 6.75
CHEMBL5555772 — IC50 = 180.0 nM 6.75
CHEMBL5558573 — IC50 = 180.0 nM 6.75
CHEMBL5557904 — IC50 = 210.0 nM 6.68
CHEMBL5505876 — IC50 = 230.0 nM 6.64
CHEMBL5559511 — IC50 = 280.0 nM 6.55
CHEMBL5512507 — IC50 = 300.0 nM 6.52
CHEMBL5557117 — IC50 = 360.0 nM 6.44
CHEMBL5523413 — IC50 = 400.0 nM 6.40
CHEMBL5532571 — IC50 = 400.0 nM 6.40
CHEMBL5517898 — IC50 = 420.0 nM 6.38
CHEMBL5556895 — IC50 = 430.0 nM 6.37
CHEMBL5532024 — IC50 = 440.0 nM 6.36
CHEMBL5542322 — IC50 = 460.0 nM 6.34
CHEMBL5556256 — IC50 = 590.0 nM 6.23
CHEMBL5505759 — IC50 = 600.0 nM 6.22
CHEMBL5517904 — IC50 = 700.0 nM 6.16
CHEMBL5555797 — IC50 = 770.0 nM 6.11
CHEMBL5523576 — IC50 = 960.0 nM 6.02
CHEMBL5559193 — IC50 = 1180.0 nM 5.93
CHEMBL5556197 — IC50 = 1270.0 nM 5.90
CHEMBL5558959 — IC50 = 1300.0 nM 5.89
CHEMBL5531976 — IC50 = 1580.0 nM 5.80
CHEMBL5532209 — IC50 = 2240.0 nM 5.65
CHEMBL5557514 — IC50 = 2650.0 nM 5.58
CHEMBL5505928 — IC50 = 3060.0 nM 5.51
CHEMBL5537076 — IC50 = 3310.0 nM 5.48
CHEMBL5505894 — IC50 = 3320.0 nM 5.48
CHEMBL5512557 — IC50 = 4730.0 nM 5.33
CHEMBL5532046 — IC50 = 6270.0 nM 5.20
CHEMBL5555535 — IC50 = 7610.0 nM 5.12
CHEMBL5556303 — IC50 = 9040.0 nM 5.04
CHEMBL5558875 — IC50 = 11900.0 nM 4.92
CHEMBL5558423 — IC50 = 15080.0 nM 4.82