Assay Detail

CHEMBL5502994

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ADMET

Inhibition of CYP2C9 (unknown origin)

ChEMBL ↗

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Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

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Cytochrome P450 2C9 (CHEMBL3397) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2C9

CHEMBL3397

Anchored from Assay target.

Protein identity Cytochrome P450 2C9

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 2C9 (CHEMBL3397) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.

Himmelbauer MK, Bajrami B, Basile R, Capacci A, Chen T, Choi CK, Gilfillan R, Gonzalez-Lopez de Turiso F, Gu C, Hoemberger M, Johnson DS, Jones JH, Kadakia E, Kirkland M, Lin EY, Liu Y, Ma B, Magee T, Mantena S, Marx IE, Metrick CM, Mingueneau M, Murugan P, Muste CA, Nadella P, Nevalainen M, Parker Harp CR, Pattaropong V, Pietrasiewicz A, Prince RJ, Purgett TJ, Santoro JC, Schulz J, Sciabola S, Tang H, Vandeveer HG, Wang T, Yousaf Z, Helal CJ, Hopkins BT.
J Med Chem (2024) 67 : 8122 -8140
PubMed 38712838 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.28	5.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5532458	—	—	1	5.28

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5532458	—	IC50	=	5200.0	nM	5.28