Assay Detail
Binding
CHEMBL5503079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin) by HTRF kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent discovery and development of AXL inhibitors as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.70 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314429 | TAMNORZATINIB | 2.0 | 1 | 9.15 |
| CHEMBL5314428 | ZANZALINTINIB | 3.0 | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314429 | TAMNORZATINIB | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5314428 | ZANZALINTINIB | IC50 | = | 5.8 | nM | 8.24 |