Compound Detail
CHEMBL5314428
ZANZALINTINIB 🧪 Phase III
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🧪 Phase III
CNC(=O)c1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)ccnc2cc1OC
Basic Information
| ChEMBL ID | CHEMBL5314428 |
| Name | ZANZALINTINIB |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | JSPCKALGNNVYOO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
4
Known Names
7
Indications
Molecular Properties
528.5
MW (Da)
4.89
ALogP
6
HBA
3
HBD
118.7
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Carcinoma, Renal Cell Carcinoma, Renal Cell Carcinoma, Renal Cell Colorectal Neoplasms Carcinoma, Squamous Cell Neoplasms Carcinoma, Non-Small-Cell Lung
Activity Summary
IC50 1 meas. best 8.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 8.24 | 8.24 | 5.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor UFO | IC50 | = | 5.8 | nM | 8.24 | Inhibition of AXL (unknown origin) by HTRF kinase assay | 38714043 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38714043 | 10.1016/j.ejmech.2024.116475 | Tyrosine-protein kinase receptor UFO | 1 |
Data from ChEMBL 36 via Core Engine