Assay Detail
Binding
CHEMBL5504539
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Binding affinity to human alpha2B-adrenoceptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing Chromane Derivatives as α<sub>2A</sub>-Adrenoceptor Selective Agonists via Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.26 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5517941 | — | — | 1 | 9.60 |
| CHEMBL5542553 | — | — | 1 | 8.76 |
| CHEMBL5542211 | — | — | 1 | 7.45 |
| CHEMBL5517987 | — | — | 1 | 7.22 |
| CHEMBL4594267 | TASIPIMIDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5517941 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL5542553 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL5542211 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL5517987 | — | Ki | = | 60.26 | nM | 7.22 |
| CHEMBL4594267 | TASIPIMIDINE | Ki | > | 1000.0 | nM | - |