Assay Detail
Binding
CHEMBL5504540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human alpha2C-adrenoceptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Designing Chromane Derivatives as α<sub>2A</sub>-Adrenoceptor Selective Agonists via Conformation Constraint.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.27 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5517941 | — | — | 1 | 9.50 |
| CHEMBL5542211 | — | — | 1 | 7.75 |
| CHEMBL5542553 | — | — | 1 | 7.56 |
| CHEMBL4594267 | TASIPIMIDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5517941 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL5542211 | — | Ki | = | 17.78 | nM | 7.75 |
| CHEMBL5542553 | — | Ki | = | 27.54 | nM | 7.56 |
| CHEMBL4594267 | TASIPIMIDINE | Ki | > | 1000.0 | nM | - |