Assay Detail
Binding
CHEMBL5504732
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AXL (unknown origin) preincubated for 15 mins followed by substrate and ATP addition and measured after 3 hrs by ADP-Glo kinase assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.89 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314429 | TAMNORZATINIB | 2.0 | 1 | 8.66 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 8.48 |
| CHEMBL5512537 | — | — | 1 | 8.42 |
| CHEMBL5532530 | — | — | 1 | 8.18 |
| CHEMBL5557044 | — | — | 1 | 8.14 |
| CHEMBL5556349 | — | — | 1 | 8.12 |
| CHEMBL5517863 | — | — | 1 | 8.10 |
| CHEMBL5555723 | — | — | 1 | 8.09 |
| CHEMBL5542282 | — | — | 1 | 8.07 |
| CHEMBL5557391 | — | — | 1 | 8.04 |
| CHEMBL5556050 | — | — | 1 | 8.04 |
| CHEMBL5558836 | — | — | 1 | 8.00 |
| CHEMBL5559274 | — | — | 1 | 7.99 |
| CHEMBL5559385 | — | — | 1 | 7.97 |
| CHEMBL5555377 | — | — | 1 | 7.96 |
| CHEMBL3326006 | — | — | 1 | 7.94 |
| CHEMBL5532211 | — | — | 1 | 7.92 |
| CHEMBL5505936 | — | — | 1 | 7.86 |
| CHEMBL5558074 | — | — | 1 | 7.80 |
| CHEMBL5559259 | — | — | 1 | 7.80 |
| CHEMBL5558002 | — | — | 1 | 7.74 |
| CHEMBL5523590 | — | — | 1 | 7.73 |
| CHEMBL5557417 | — | — | 1 | 7.67 |
| CHEMBL5558655 | — | — | 1 | 7.24 |
| CHEMBL5542329 | — | — | 1 | 7.18 |
| CHEMBL5505865 | — | — | 1 | 7.09 |
| CHEMBL5512532 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314429 | TAMNORZATINIB | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5512537 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5532530 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5557044 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL5556349 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5517863 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5555723 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5542282 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5557391 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5556050 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5558836 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL5559274 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5559385 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL5555377 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL3326006 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5532211 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL5505936 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL5558074 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5559259 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5558002 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL5523590 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL5557417 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL5558655 | — | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL5542329 | — | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL5505865 | — | IC50 | = | 80.3 | nM | 7.09 |
| CHEMBL5512532 | — | IC50 | = | 175.2 | nM | 6.76 |