Compound Detail
CHEMBL5555377
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CN1CCN(c2cccc(-c3c(-c4cnn(C)c4)oc4ncnc(Oc5ccc(NC(=O)c6cccn(-c7ccc(F)cc7)c6=O)cc5)c34)c2)CC1
Basic Information
| ChEMBL ID | CHEMBL5555377 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTBNTDYEJRQXQB-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
5
PK Parameters
3
Publications
0
Known Names
Molecular Properties
696.7
MW (Da)
6.38
ALogP
11
HBA
1
HBD
123.5
PSA (Ų)
0.19
QED
3
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Mer CHEMBL5331 | IC50 | 8.12 | 7.985 | 7.5 | 2 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 7.96 | 7.96 | 11.1 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 87.1 | mL.min-1.kg-1 | Mus musculus |
| F | 14.8 | % | Mus musculus |
| T1/2 | 2.4 | hr | Mus musculus |
| T1/2 | 4.3 | hr | Mus musculus |
| Tmax | 2.7 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Mer | IC50 | = | 7.5 | nM | 8.12 | Inhibition of MER (unknown origin) expressed in mouse BaF3 cells co-expressing T... | 38913493 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 11.1 | nM | 7.96 | Inhibition of AXL (unknown origin) preincubated for 15 mins followed by substrat... | 38913493 |
| Tyrosine-protein kinase Mer | IC50 | = | 14.2 | nM | 7.85 | Inhibition of MER (unknown origin) preincubated for 15 mins followed by substrat... | 38913493 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38913493 | 10.1021/acs.jmedchem.4c00400 | ADMET | 10 |
| 38913493 | 10.1021/acs.jmedchem.4c00400 | Tyrosine-protein kinase Mer | 2 |
| 38913493 | 10.1021/acs.jmedchem.4c00400 | Tyrosine-protein kinase receptor UFO | 1 |
Data from ChEMBL 36 via Core Engine