Assay Detail

CHEMBL5505345

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Functional

Antitrypanosomal activity against Trypanosoma brucei

ChEMBL ↗

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Target

Trypanosoma brucei (CHEMBL612849) ↗

Open DB target context

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Trypanosoma brucei (CHEMBL612849) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei

CHEMBL612849

Anchored from Assay target.

Protein identity Trypanosoma brucei

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei (CHEMBL612849) ↗

Type	ORGANISM
Organism	Trypanosoma brucei

Publication

Structure-Activity Study on Substituted, Core-Extended, and Dyad Naphthalene Diimide G-Quadruplex Ligands Leading to Potent Antitrypanosomal Agents.

Benassi A, Peñalver P, Pérez-Soto M, Pirota V, Freccero M, Morales JC, Doria F.
J Med Chem (2024) 67 : 10643 -10654
PubMed 38924701 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL55	PENTAMIDINE	4.0	1	9.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL55	PENTAMIDINE	IC50	=	0.2	nM	9.70