Assay Detail
Binding
CHEMBL5505512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TMPRSS2 (unknown origin) using Boc-Gln-Ala-Arg-AMC as peptide substrate pre-incubated with compound for 30 mins followed by substrate addition by fluorescence based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New Strategies for Responding to SARS-CoV-2: The Present and Future of Dual-Target Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 9.00 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL35241 | DIMINAZENE | IC50 | = | 1350.0 | nM | 5.87 |