Assay Detail
Functional
CHEMBL5506546
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Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.47 | 6.82 |
| IC50 | 2 | 6.72 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222286 | — | — | 1 | 6.82 |
| CHEMBL223735 | — | — | 1 | 6.80 |
| CHEMBL382085 | — | — | 1 | 6.75 |
| CHEMBL196317 | — | — | 1 | 6.68 |
| CHEMBL396100 | — | — | 1 | 6.62 |
| CHEMBL374761 | — | — | 1 | 6.55 |
| CHEMBL374521 | — | — | 1 | 6.54 |
| CHEMBL5562000 | — | — | 1 | 6.40 |
| CHEMBL387398 | — | — | 1 | 6.34 |
| CHEMBL221781 | — | — | 1 | 6.12 |
| CHEMBL398682 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222286 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL223735 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL382085 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL196317 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL396100 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL374761 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL374521 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5562000 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL387398 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL221781 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL398682 | — | EC50 | = | 1000.0 | nM | 6.00 |