Assay Detail
Binding
CHEMBL5506579
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Inhibition of RIPK3 (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 3 (CHEMBL1795199) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.72 | 7.72 |
| IC5 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214141 | — | — | 1 | 7.72 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | - |
| CHEMBL5567128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214141 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL223360 | LINIFANIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL5567128 | — | IC5 | < | 0.25 | uM | - |