Assay Detail
Functional
CHEMBL5506720
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Agonist activity at human recombinant mGluR2 receptor assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation incubated for 20 mins by SPA kit analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334160 | — | — | 1 | 8.10 |
| CHEMBL5565734 | — | — | 1 | 8.10 |
| CHEMBL280563 | — | — | 1 | 6.52 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.40 |
| CHEMBL34453 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334160 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5565734 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL280563 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL34453 | — | EC50 | = | 12000.0 | nM | 4.92 |