Compound Detail
CHEMBL5565734
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5565734 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CQOQGFPPQJNODN-STGXQOJASA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
189.2
MW (Da)
-1.66
ALogP
4
HBA
4
HBD
120.8
PSA (Ų)
0.42
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL2851 | EC50 | 8.4 | 8.4 | 4.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL3067 | EC50 | 8.15 | 8.15 | 7.0 | 1 |
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 8.1 | 8.1 | 8.0 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | EC50 | 7.42 | 7.42 | 38.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 4.0 | nM | 8.4 | Agonist activity at rat mGlu2 | 38170918 |
| Metabotropic glutamate receptor 3 | EC50 | = | 7.0 | nM | 8.15 | Agonist activity at rat mGlu3 | 38170918 |
| Metabotropic glutamate receptor 2 | EC50 | = | 8.0 | nM | 8.1 | Agonist activity at human recombinant mGluR2 receptor assessed as inhibition of ... | 38245976 |
| Metabotropic glutamate receptor 3 | EC50 | = | 38.0 | nM | 7.42 | Agonist activity at human recombinant mGluR3 receptor assessed as inhibition of ... | 38245976 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38245976 | 10.1016/j.ejmech.2024.116157 | Metabotropic glutamate receptor 2 | 1 |
| 38245976 | 10.1016/j.ejmech.2024.116157 | Metabotropic glutamate receptor 3 | 1 |
| 38170918 | 10.1021/acs.jmedchem.3c01811 | Metabotropic glutamate receptor 2 | 1 |
| 38170918 | 10.1021/acs.jmedchem.3c01811 | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine