Assay Detail
Functional
CHEMBL5507160
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Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558185 | — | — | 1 | 5.31 |
| CHEMBL5555788 | — | — | 1 | 4.87 |
| CHEMBL5560228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558185 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5555788 | — | IC50 | = | 13640.0 | nM | 4.87 |
| CHEMBL5560228 | — | IC50 | > | 8000.0 | nM | - |