Assay Detail
Binding
CHEMBL5507161
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Activation of IL-2 in human Jurkat cells incubated for 24 hrs by ELISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.06 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560228 | — | — | 1 | 7.94 |
| CHEMBL5557745 | — | — | 1 | 7.34 |
| CHEMBL5523660 | — | — | 1 | 7.14 |
| CHEMBL5558965 | — | — | 1 | 7.04 |
| CHEMBL5557243 | — | — | 1 | 7.01 |
| CHEMBL5561221 | — | — | 1 | 6.96 |
| CHEMBL5560445 | — | — | 1 | 6.56 |
| CHEMBL5557809 | — | — | 1 | 6.52 |
| CHEMBL5560869 | — | — | 1 | - |
| CHEMBL5561074 | — | — | 1 | - |
| CHEMBL5566879 | — | — | 1 | - |
| CHEMBL5556918 | — | — | 1 | - |
| CHEMBL5542831 | — | — | 1 | - |
| CHEMBL5567804 | — | — | 1 | - |
| CHEMBL5557081 | — | — | 1 | - |
| CHEMBL5556436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560228 | — | EC50 | = | 11.56 | nM | 7.94 |
| CHEMBL5557745 | — | EC50 | = | 45.37 | nM | 7.34 |
| CHEMBL5523660 | — | EC50 | = | 72.91 | nM | 7.14 |
| CHEMBL5558965 | — | EC50 | = | 90.4 | nM | 7.04 |
| CHEMBL5557243 | — | EC50 | = | 97.27 | nM | 7.01 |
| CHEMBL5561221 | — | EC50 | = | 108.39 | nM | 6.96 |
| CHEMBL5560445 | — | EC50 | = | 275.03 | nM | 6.56 |
| CHEMBL5557809 | — | EC50 | = | 305.0 | nM | 6.52 |
| CHEMBL5560869 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5561074 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5566879 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5556918 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5542831 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5567804 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5557081 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5556436 | — | EC50 | > | 10000.0 | nM | - |