Compound Detail
CHEMBL5557745
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Basic Information
| ChEMBL ID | CHEMBL5557745 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FBVLBABBNHSLQA-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
414.5
MW (Da)
5.81
ALogP
4
HBA
1
HBD
56.4
PSA (Ų)
0.45
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.34
IC50 1 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-2 CHEMBL5880 | EC50 | 7.34 | 7.34 | 45.4 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 1 CHEMBL5749 | IC50 | 7.02 | 7.02 | 95.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-2 | EC50 | = | 45.37 | nM | 7.34 | Activation of IL-2 in human Jurkat cells incubated for 24 hrs by ELISA | 38350360 |
| Mitogen-activated protein kinase kinase kinase kinase 1 | IC50 | = | 95.76 | nM | 7.02 | Inhibition of HPK1 (unknown origin) preincubated for 10 mins followed by ATP add... | 38350360 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38350360 | 10.1016/j.ejmech.2024.116206 | Interleukin-2 | 2 |
| 38350360 | 10.1016/j.ejmech.2024.116206 | Mitogen-activated protein kinase kinase kinase kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine