Assay Detail
Binding
CHEMBL5507465
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Inhibition of exosomal PD-L1 (unknown origin) generation preincubated with compound for 24 hrs followed by strep-d2 acceptor bead addition and measured after 30 mins by HTRF assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of the exosomal PD-L1 inhibitor to promote the PD-1 targeting therapy of gastric cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.16 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555873 | — | — | 1 | 6.97 |
| CHEMBL5559890 | — | — | 1 | 6.82 |
| CHEMBL5558040 | — | — | 1 | 6.66 |
| CHEMBL5565450 | — | — | 1 | 6.54 |
| CHEMBL5556505 | — | — | 1 | 6.47 |
| CHEMBL5563818 | — | — | 1 | 6.34 |
| CHEMBL5527974 | — | — | 1 | 6.30 |
| CHEMBL5556086 | — | — | 1 | 6.24 |
| CHEMBL5559214 | — | — | 1 | 6.21 |
| CHEMBL5562493 | — | — | 1 | 6.19 |
| CHEMBL5568425 | — | — | 1 | 6.17 |
| CHEMBL5556986 | — | — | 1 | 6.17 |
| CHEMBL5556271 | — | — | 1 | 6.12 |
| CHEMBL1516633 | — | — | 1 | 5.81 |
| CHEMBL5523513 | — | — | 1 | 5.65 |
| CHEMBL5566429 | — | — | 1 | 5.59 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 5.41 |
| CHEMBL5559755 | — | — | 1 | 5.17 |
| CHEMBL5557337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555873 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL5559890 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5558040 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5565450 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL5556505 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL5563818 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL5527974 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL5556086 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL5559214 | — | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL5562493 | — | IC50 | = | 648.0 | nM | 6.19 |
| CHEMBL5568425 | — | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL5556986 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL5556271 | — | IC50 | = | 753.0 | nM | 6.12 |
| CHEMBL1516633 | — | IC50 | = | 1544.0 | nM | 5.81 |
| CHEMBL5523513 | — | IC50 | = | 2241.0 | nM | 5.65 |
| CHEMBL5566429 | — | IC50 | = | 2586.0 | nM | 5.59 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 3865.0 | nM | 5.41 |
| CHEMBL5559755 | — | IC50 | = | 6817.0 | nM | 5.17 |
| CHEMBL5557337 | — | IC50 | > | 10000.0 | nM | - |