Assay Detail
Binding
CHEMBL5507790
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Inhibition of AAK1 (unknown origin)
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazine-based AAK1 inhibitors with anti-viral property against SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.14 | 8.92 |
| Ki | 1 | 8.04 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089410 | PILAVAPADIN | 2.0 | 1 | 8.92 |
| CHEMBL4439128 | — | — | 1 | 8.40 |
| CHEMBL4855590 | — | — | 1 | 8.32 |
| CHEMBL5202351 | — | — | 1 | 8.24 |
| CHEMBL4452939 | — | — | 1 | 8.04 |
| CHEMBL5564665 | — | — | 1 | 7.95 |
| CHEMBL4872886 | — | — | 1 | 7.92 |
| CHEMBL516312 | — | — | 1 | 7.24 |
| CHEMBL4127773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089410 | PILAVAPADIN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4439128 | — | IC50 | = | 4.02 | nM | 8.40 |
| CHEMBL4855590 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5202351 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4452939 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL5564665 | — | IC50 | = | 11.19 | nM | 7.95 |
| CHEMBL4872886 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL516312 | — | IC50 | = | 57.81 | nM | 7.24 |
| CHEMBL4127773 | — | IC50 | < | 10.0 | nM | - |