Compound Detail
CHEMBL5564665
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5564665 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TVZWWNJPVPFXBW-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
427.5
MW (Da)
3.47
ALogP
6
HBA
2
HBD
92.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| AP2-associated protein kinase 1 CHEMBL3830 | IC50 | 7.95 | 7.95 | 11.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| AP2-associated protein kinase 1 | IC50 | = | 11.19 | nM | 7.95 | Inhibition of AAK1 (unknown origin) | 38377825 |
| AP2-associated protein kinase 1 | IC50 | = | 11.19 | nM | 7.95 | Inhibition of GST-tagged recombinant human AAK1 (1 to 510 residues) expressed in... | 38377825 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38377825 | 10.1016/j.ejmech.2024.116232 | AP2-associated protein kinase 1 | 2 |
Data from ChEMBL 36 via Core Engine