Assay Detail
ADMET
CHEMBL5511461
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Inhibition of CYP2D6 (unknown origin) using dextromethorphan as substrate preincubated for 5 min followed by NADPH addition and measured after 15 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.30 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5561914 | — | — | 1 | 7.54 |
| CHEMBL5567870 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5561914 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL5567870 | — | IC50 | = | 87.4 | nM | 7.06 |