Assay Detail
Binding
CHEMBL5513489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MDM4/p53 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Tumour suppressor protein p53/Mdm4 (CHEMBL2221344) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.44 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359965 | ALLICIN | 2.0 | 1 | 7.96 |
| CHEMBL5314346 | VERTEPORFIN | 4.0 | 1 | 5.95 |
| CHEMBL231884 | DIOSMIN | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359965 | ALLICIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5314346 | VERTEPORFIN | IC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL231884 | DIOSMIN | IC50 | = | 3890.0 | nM | 5.41 |